![]() Following the release of neurotransmitters at the endplate, excitatory or inhibitory postsynaptic potentials (EPSP/IPSP) are generated secondary to neuronal depolarization (in the case of EPSP with intracellular sodium influx resulting in extracellular negativity) or hyperpolarization (in the case of IPSP intracellular negativity). The pyramidal cell bodies are mostly present in layers 3 and 5 of the cerebral cortex. An estimated cortical area of 10 cm2 discharging synchronously is required to generate a deflection on scalp EEG. They measure the absolute electrical potentials generated by the neurons of the underlying cerebral cortex. The electroencephalogram recording electrodes are placed over the scalp.
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